Desferal – When Not To Use

If you have a contraindicating medical problem(s):
1. Changes in vision or hearing pending evaluation
2. Allergic reactions to Desferal, especially if severe, i.e. anaphylactic shock

If you have fever over 101 F:
- If you have a temperature of above 101 F, you must discontinue use of Desferal and notify your doctor. Having a temperature may be an indication of a bacterial infection. Bacteria can utilize Desferal in the body to grow rapidly and bacteria tend to thrive in iron-rich environments.

- If you have fever, consult with your doctor and remind your doctor about Yersinia, a strain of bacteria that is particularly harmful to patients on Desferal. Do not restart Desferal until you have consulted with your doctor or until you have finished your course of antibiotics.

If you are taking certain medicines:
1. Your doctor needs to be aware if you are taking medications that contain prochlorperazine, such as Compazine, a drug used for anti-nausea and psychosis.

2. If you are taking antibiotics for a bacterial infection, you should consult with your doctor before starting Desferal with the exception of taking penicillin prophylaxis following a splenectomy.

Sometimes when taking Vitamin C:
Vitamin C supplements should not exceed 200 mg a day and should only be taken at the start of infusion. Vitamin C should not be taken at all on days when you are not using Desferal.

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How to mix your Desferal?

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Mixing & Making Desferal
How to Mix Your Desferal

The first thing you need to do before you begin mixing is the most important step when mixing your Desferal: Wash your hands with soap and water for 3 minutes! Unclean hands can cause infection.
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What supplies or other materials, will I need to use Desferal subcutaneously?

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Desferal Supplies
You’ll need the following supplies to do you Desferal. Remember there are different types and sizes of some supplies, like needles and syringes. You can obtain these from your pharmacist or home healthcare agency beforehand. Check with your doctor or other patients to keep up on the latest supplies.
Desferal
The company which manufactures it is [...]

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Can you use Desferal while breastfeeding?

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Breast-feeding While On Desferal
Desferal in breast milk is not a concern for the baby because the baby cannot absorb it.

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Can you use Desferal if you are pregnant?

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Desferal And Pregnancy
Desferal may be harmful to the unborn child and therefore consideration needs to given to stopping Desferal if you are thinking about having a child. Since the effect of Desferal on the fetus is not known with certainty, many doctors recommend stopping Desferal during pregnancy, at least until the completion of the first [...]

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Is it true that Desferal can make some infections worse?

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Desferal and Infections
Some infections that are not usually severe can be made worse by Desferal. This is particularly true for infections with Yersinia, This can cause fever, abdominal pain and diarrhoea. If you get these symptoms you should stop your Desferal at once, and call your doctor, or visit the Thalassaemia centre as soon as [...]

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Can Desferal cause any other problems?

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Desferal And Other Problems
Desferal can cause disturbances of the eyes, and of hearing, and can cause slowing of growth, if too high doses are given. As a rule, such problems occur only when high doses of Desferal are used, and when the iron overload is not severe. They can usually be reversed by decreasing the [...]

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Can Desferal cause bad reactions, at the place where it is injected, or generally?

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Desferal And Bad Reactions
In a very few people, injecting Desferal has caused a general reaction. These reactions have been of several types: feeling generally unwell, tingling, dizziness, difficulty in breathing etc. If any of these things happen, the injection should be stopped immediately. General reactions do not happen without warning in patients on regular treatment. [...]

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How do you give Desferal into a muscle?

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Desferal Into Muscle
One vial of 500 mg can be dissolved in 2 ml of distilled water, and injected into a muscle of the arm or leg. It may be a bit more effective to divide it into two separate injections, given on the same day.

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How do you give Desferal with blood transfusions?

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Desferal With Transfusions
At many centres, Desferal is given into the vein at the same time that blood is given. It is usually forbidden to inject Desferal (or anything else) into the bag of blood being transfused, because of the small risk of infecting the blood. 500 mg of Desferal (or even 1 or 2 grams [...]

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